Salamanca is known as a quite fancy residential district of Madrid. Living is quite expensive there. Palaces and noble town houses characterize the outward appearance of the district.
The night life is not very active in Salamanca. Its citizens prefer and cosy and calm atmosphere.
Tourist should visit Salamanca if there is an interest for fancy, exclusive, and expensive shops. Those shops are located in Calle Serrano.
If you like partying and a lot of crazy people, Salamanca might not be the right holiday destination for you.